I was educated at Trinity College, Cambridge, and received a BA in Natural Sciences in 1985 and my PhD in 1989, having worked on the role of calcium oscillations in cell activation in Michael Berridge's laboratory.
After a short spell at UCL working on mammalian fertilisation with Michael Whitaker, I went to Johns Hopkins University as a Harkness Fellow studying the role of calcium signals in early development. Returning to the UK in 1991, I joined the Department of Pharmacology. I have been successively a Beit Memorial Fellow, Wellcome Trust Career Development Fellow and Wellcome Trust Senior Fellow in Basic Biomedical Research.
I was elected to a Tutorial Fellowship at New College in 1998 in conjunction with a proleptic University appointment, appointed to a titular Professor of Pharmacology in 2002, and elected to the Professorship of Pharmacology and a Professorial Fellowship at LMH in 2006. I was Head of the Department of Pharmacology from 2006-2015.
I received the 2001 Novartis Prize of the British Pharmacological Society for my scientific contributions to pharmacology. I was elected as a Fellow of the Academy of Medical Sciences in 2010 for my contributions to the advancement of medical science. In 2016 I was elected as a Fellow of The Royal Society.
My research work has led to the identification of new biochemical pathways controlling calcium signals that regulate processes as diverse as fertilisation, secretion, contractility and neuronal excitability using a multidisciplinary approach based on confocal microscopy, video-imaging, electrophysiology, flash photolysis, microsomal calcium flux measurements and molecular and biochemical techniques.