Dr Eleanor Conole

I joined LMH in 2024 as a JRF in Applied AI affiliated with the department of Biochemistry. Previously I worked as a postdoc in the Lothian Birth Cohorts group at the University of Edinburgh researching the neurobiology of age-related cognitive change. My PhD was funded by the Wellcome Trust and examined how chronic inflammation relates to brain ageing, with a focus on the utility of proteomic and DNA methylation surrogates of inflammation and their association with cognitive and neuroimaging outcomes across the lifecourse. Prior to my doctoral studies, I completed a Masters by Research degree in Neuroscience and a Bachelor’s degree in Neuroscience. 

My research interests are in the application of AI to address clinical problems and the development of peripheral-based biomarkers to stratify disease and monitor health trajectories. I work in the field of neuroimaging-genomics, with a specialist interest in the immune mechanisms of accelerated brain ageing. My current research is set across different population cohorts looking at the application of AI to multi-omics and neuroimaging. 

I am a member of the Alan Turing special interest group in Clinical AI and on the committee of the Molecular Epidemiology Group UK (MEG-UK).

Baranyi, G., Buchanan, C. R., Conole, E. L. S., Backhouse, E. V., Maniega, S. M., Valdés Hernández, M. del C., Bastin, M. E., Wardlaw, J., Deary, I. J., Cox, S. R., & Pearce, J. (2024). Life-course neighbourhood deprivation and brain structure in older adults: The Lothian Birth Cohort 1936. Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02591-9

Jaggi, A., Conole, E. L. S., Raisi-Estabragh, Z., Gkontra, P., McCracken, C., Szabo, L., Neubauer, S., Petersen, S. E., Cox, S. R., & Lekadir, K. (2024). A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function. Imaging Neuroscience, 2, 1–18. https://doi.org/10.1162/imag_a_00063

Conole, E. L. S., Vaher, K., Cabez, M. B., Sullivan, G., Stevenson, A. J., Hall, J., Murphy, L., Thrippleton, M. J., Quigley, A. J., Bastin, M. E., Miron, V. E., Whalley, H. C., Marioni, R. E., Boardman, J. P., & Cox, S. R. (2023). Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders. Brain, Behavior, and Immunity, 110, 322–338. https://doi.org/10.1016/j.bbi.2023.03.011

McCartney, D. L., Hillary, R. F., Conole, E. L. S., Banos, D. T., Gadd, D. A., Walker, R. M., Nangle, C., Flaig, R., Campbell, A., Murray, A. D., Maniega, S. M., Valdés-Hernández, M. del C., Harris, M. A., Bastin, M. E., Wardlaw, J. M., Harris, S. E., Porteous, D. J., Tucker-Drob, E. M., McIntosh, A. M., … Marioni, R. E. (2022). Blood-based epigenome-wide analyses of cognitive abilities. Genome Biology, 23(1), 26. https://doi.org/10.1186/s13059-021-02596-5

Conole, E. L. S., Stevenson, A. J., Muñoz Maniega, S., Harris, S. E., Green, C., Valdés Hernández, M. del C., Harris, M. A., Bastin, M. E., Wardlaw, J. M., Deary, I. J., Miron, V. E., Whalley, H. C., Marioni, R. E., & Cox, S. R. (2021). DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging. Neurology, 97(23), e2340. https://doi.org/10.1212/WNL.0000000000012997

Green, C., Shen, X., Stevenson, A. J., Conole, E. L. S., Harris, M. A., Barbu, M. C., Hawkins, E. L., Adams, M. J., Hillary, R. F., Lawrie, S. M., Evans, K. L., Walker, R. M., Morris, S. W., Porteous, D. J., Wardlaw, J. M., Steele, J. D., Waiter, G. D., Sandu, A.-L., Campbell, A., Whalley, H. C. (2021). Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder. Brain, Behavior, and Immunity, 92, 39–48. https://doi.org/10.1016/j.bbi.2020.11.024

Full publication list: https://scholar.google.com/citations?user=klj4X0sAAAAJ&hl=en